ADMEcell Will Be Exhibiting At The AAPS Meeting Oct 24-27 Booth #1559

Posted by Sandy Koshkin on Thu, Oct 13, 2011 @ 11:50 AM

ADMEcell To Exhibit At The AAPS Meeting IN Washington DC Oct 25-27

ADMEcell will join over 500 exhibitors at the upcoming AAPS meeting in Washinton DC October 25 through October 27.  This is the 25th anniversary of the AAPS meeting which will include speakers such as Janet Woodcock, M.D., director of the Center for Drug EvaluatioAAPS Meetingn and Research at the Food and Drug Administration, who will provide her view on the future of regulations. John Lechleiter, Ph.D., president and chief executive officer, Eli Lilly and Company, will speak to the future shape of the global pharmaceutical industry; Francis S. Collins, M.D., Ph.D., director, U.S. National Institutes of Health, will speak on current research that may lead to new therapies in the future. Sir Michael Rawlins, M.D., chairman of the National Institute of Health & Clinical Excellence (NICE) of the United Kingdom, will speak on the cost benefits of therapies and the societal ability to pay for the therapies, "Value for Money in Healthcare: The Future." NICE is an independent organization responsible for providing national guidance on promoting good health and preventing and treating ill health.

ADMEcell will showcase its three product lines for providing tools for drug discovery and development:

Cell based Assays: Caco-2, MDR-1, BCRP & BBB Permeability

ELISA Kits For Monoclonal Antibody Assessment: Quantification kits for Human, Mouse, Rat & Bovine IgG and Mouse Ig Isotyping

Protein Binding Kits For HAS and AGP

Please plan to visit us at Exhibit #1559

Tags: transporters, ELISA Kits, Human IgG Kits, Mouse IgG Kits, Rat Igg Kits, Mouse Isotyping Kits, Ready To Use Assays, Ready To Use Kits, aaps meeting, aaps exhibition, caco-2 assay, cell based assays, MDR1 Kits, Protein Binding Kits, Blood Brain Absorption Kits, Caco-2 Kits

Overview of ADME-Tox Market Emphasis On In-Vitro Kits

Posted by Sandy Koshkin on Thu, Sep 22, 2011 @ 04:03 PM

Caco Monolayer 

The ADME Tox in vitro human testing market is estimated at over $500 million in 2011 with a healthy growth rate over 15% per year through 2015.  This market is made up of CYP450 inhibition assays, human PK predictive assays, Liver Hepatocytes and Cell-Based Assays such as Caco-2, MDR-1  BCRP and BBB (Blood Brain Barrier), to name a few (  The largest share of the market is Hepatocytes testing as they closely resemble the in vivo testing. Currently, Pharma and Biotech companies rely heavily on making these assays in house. With Ready To Use Assay Kits for common applications such as Caco-2, MDR-1, BCRP and BBB, the  Pharma and Biotech companies could save enormous amounts of time and resources in their drug discovery and development processes.

The future of Ready-to-Use In Vitro Assay Kits is bright.  Additional assay development in the drug transporters field will lead to more available Ready to Use Kits.

Tags: transporters, ELISA Kits, Human IgG Kits, in vitro, in vitro assays, cell based assays, in vitro models caco-2 assay, MDR1 Kits

Ready To Use Human/Mouse IgG Kits As Tools in Drug Discovery

Posted by Sandy Koshkin on Wed, Aug 24, 2011 @ 11:23 AM

Monoclonal AntibodiesThe economic recession has not inhibited the growth of FDA approved antibody drugs and the market for these drugs.  So far treatments for Cancer, Arthritis, Autoimmune diseases and Transplant rejection have dominated the class of drugs derived from monoclonal antibodies. The future products will include additional drugs for treatment of the above diseases and others such as Osteoporosis and Asthma.

Monoclonal antibody derived therapeutics have become a significant part of the overall drug market boasting over $40 billion in sales as of 2010 and is likely to double in the next ten years. The development of monoclonal  antibodies continues to grow and  clearly, faster ready-to-use kits to help rapid determination of the IgG levels in such antibodies remain important tools in the drug discovery and development process.

All major pharmaceutical and biotech companies have active programs in developing monoclonal antibodies. Smaller biotech companies focus on developing such antibodies only, whereas universities and research institutions utilize grants to discover new targets with monoclonal antibody technologies.

ADMEcell  and RD-Biotech (Besancon, France) offer a new line of Ready-To-Use 30 minute assay kits to quantitate Human, Mouse, Rat and Bovine IgG in cell culture supernatant, ascites and serum-all assays covering a wide dynamic range (i.e. 16-1000ng/ml for human IgG). Color coded buffer solutions simplify the pipetting steps.  Recombinant or fully humanized monoclonal antibodies can be assayed. Also included in the product line is the Mouse IGg sotyping kit.

Tags: Human IgG Kits, Mouse IgG Kits, Rat Igg Kits, Mouse Isotyping Kits, Monoclonal Antibodies

DMPK Labs and Integrating New In-Vitro Assays

Posted by Sandy Koshkin on Thu, Aug 04, 2011 @ 04:45 PM

DMPK Labs and Integrating New In Vitro Assays

Improve DMPK Productivity by Using the Industry Leading Solution

Determining the Drug Metabolism and PharmacoKinetic properties of a drug is crucial to understanding its safety and efficacy before the regulatory approval process takes place.

Currently, DMPK Labs have a tremendous balancing act on their hands betweenMDR1 Plated Cells getting all the routine work completed with minimal staff and deciding on handling selected new compounds. Many of these compounds can be tested in house or contracted out to CRO.  Preparing reagents and developing in-house assays require time and resources, whereas waiting for data from an outside source uses very little resources other than money. However, Ready-to-Use Assay Kits offer a simple solution to balance the resources needed and the associated costs.

So, how does a lab begin to evaluate a newer technology such as a new in vitro assay that can be very helpful long term? In the short term, it seems like there is no time available…However, the benefits  for DMPK labs are enormous  if they can dedicate some time to evaluate for example, a Ready-To-Use cell based assay such as Caco-2 or MDCR1 or Plasma Protein Binding to compare the cost and time savings with their current methods. These assays are available at a reasonable price and produce speedy and reliable results to make the life  easier in the DMPK Labs.

Tags: transporters, ELISA Kits, Human IgG Kits, Mouse IgG Kits, Ready To Use Assays, Ready To Use Kits, caco-2 assay, cell based assays, MDR1 Kits, Protein Binding Kits, Blood Brain Absorption Kits, Caco-2 Assays

Accelerate Your Drug Development Processes By Using Ready To Use Assays

Posted by Sandy Koshkin on Wed, Jul 27, 2011 @ 05:31 PM

Accelerate Your Drug Discovery and Development Processes and Control  Your Data when Evaluating New Drug Compounds by Using Ready-to-Use Assays

State of the art Ready-to-Use Assays-  offered by ADMEcell eliminate the need for time consuming in-house reagent preparations and assay development, thereby reducing the costs and enhancing the drug discovery and development processes.  ADMEcell’s CacoReady  and PreadyPort-MDR1 Ready To Use ELISA Kits are examples of Ready-to-Use Assay Kits  for generating  permeability data for new drug candidates.  These assays eliminate the need for in-house cell culture production offering  a great deal of cost  and time savings. In addition, you will have control on generating your own data without delays.   ADMEcell also offers a number of Ready-to-Use products with the same benefits for the assessment of Plasma Protein Binding and Blood Brain Absorption of drug candidates Finally, ADMEcell ELISA-Based Ready-to-Use Assay Kits for quantification of IgG from various species and Mouse Ig Isotyping are available for rapidly and conveniently screening of therapeutic antibodies.

Once a biotech company has decided to implement this strategy,  application of the Ready-to-Use Assay Kits will surely become an important part of its long term preclinical development plan.

Tags: ELISA Kits, Human IgG Kits, Mouse IgG Kits, Ready To Use Assays, Ready To Use Kits, MDR1 Kits, Protein Binding Kits, Blood Brain Absorption Kits, Caco-2 Kits, Caco-2 Assays